Kyle Bradley, MD on X: Megaloblastic neutrophils in bone marrow

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Kyle Bradley, MD on X: B-cell prolymphocytic leukemia. Note characteristic single large nucleolus. Dx: >55% prolymphs with no hx of CLL. / X

Kyle Bradley, MD on X: These are indeed plasma cells. Plasma cells can sometimes be multinucleated and even resemble megakaryocytes! A CD138 IHC stain is shown. Also, see this post (different case)

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Williams Hematology-McGraw-Hill (2015).pdf

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Kyle Bradley, MD on X: Plasma cells can sometimes resemble megakaryocytes! One key differentiating feature: the two giant plasma cells have agranular cytoplasm. Compare to the megakaryocyte (inset). Bone marrow aspirate smear

Hematopathology Resident / Fellow Manual - Department of

Williams Hematology-McGraw-Hill (2015).pdf